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From snail slime to bee venom, 2026’s decidedly crowded skincare space is no stranger to bizarre, buzzy ingredients. The latest ingredient du jour is PDRN (polydeoxyribonucleotide), a salmon sperm–derived DNA molecule touted for its regenerative and anti-inflammatory properties.
Sure, salmon sperm-spiked serums may sound like a hard sell, but PDRN’s clinical credibility for calming inflammation and kickstarting cellular repair has made it a major player in Korean skincare for years. Lately, it’s been everywhere stateside too, popping up in glow-boosting serums and barrier-repair creams.
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